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Chinese COVID-19 vaccines have neutralizing effect on mutant strains found in South Africa, UK
Published on: 2021-03-30
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The COVID-19 vaccines that have been marketed in China have a neutralizing effect on some mutated viruses, including the ones found in the UK and South Africa, according to Sinopharm and Sinovac.
 

Sinopharm has been testing the antiviral mutation ability of vaccines already on the market in China, such as the inactivated vaccine developed by Sinopharm, to study whether the mutation of the virus would alter the efficacy of the vaccine, said Zhang Yuntao, vice president and chief scientist of China National Biotec Group (CNBG), a Sinopharm subsidiary, at a press conference on Sunday.
 

Two inactivated vaccines from Sinopharm have been used in a crossover trial on the strains found in South Africa and the UK as well as more than 10 strains found in different regions in China, using the serum after the phase II and III clinical trials in China and overseas, he said.
 

The results showed that the neutralizing antibodies produced by the two inactivated vaccines neutralized these strains well.
 

He also noted that Sinopharm is conducting neutralization trial monitoring on the strains found in Brazil and Zimbabwe.
 

At the press conference, Gao Qiang, general manager of Sinovac, another producer of COVID-19 vaccines, said that Sinovac has also carried out studies on the protection of its CoronaVac vaccine against the variant strains found in various countries in cooperation with several research institutions.
 

Sinopharm carried out neutralization trials on the variant strains in 10 countries during the initial stage of the study and the results showed that the vaccine developed at the time was protective against the variant strains discovered in each country, Zhang said.
 

Sinovac also used the strain discovered in Wuhan and the newly mutated strains found in the UK and South Africa to conduct the neutralizing antibody detection of immune serum after vaccination in 2021, and test results showed that the seroconversion rate was 100 percent after a dose of vaccine against the strains found in Wuhan and the UK, and 97 percent against the strains discovered in South Africa. The overall antibody level between the strains discovered in Wuhan and the UK was basically the same, he said.
 

我国新冠疫苗对大多数病毒变异株仍具有效性

我国疫苗对大多数病毒变异株仍具有效性,个别毒株在监测中
 

病毒变异是一个全球都非常关注的问题,对于国外的病毒变异,我国疫苗的有效性是否有影响?对此,张云涛表示,目前英国、南非发现的变异株具有代表性,对新冠疫苗提出了新挑战。
 

他介绍,国药集团中国生物的两款灭活疫苗,利用在国内和海外Ⅱ期、Ⅲ期临床试验后的血清,对包括南非发现的、英国发现的毒株,还有国内不同地区发现的10多株毒株进行了交叉综合实验。结果显示,两款灭活疫苗产生的中和抗体对这些毒株都有很好的中和作用。目前在巴西、津巴布韦发现的毒株,正在进行中和实验监测。
 

高强表示,科兴中维与多家研究机构合作开展了新冠疫苗克尔来福对各个国家变异株的保护性研究,在研究初期已对10个国家病毒株的变异进行中和试验,证明当时研发的疫苗对各个国家的变异株是有作用的。
 

检测结果显示,武汉株、英国株这两株病毒对疫苗免疫的血清是可以达到100%阳转的,南非株可以达到97%阳转,整体的抗体水平武汉株和英国株基本没有差异,但是南非株的情况有些不同。“我们已启动对南非株、巴西株的疫苗研发工作,南非株的相关疫苗研究工作已经开展了,巴西株的引进正在过程当中。”高强说。

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