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Different vaccine for booster shots recommended
Published on: 2022-04-12
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China's top respiratory disease expert Zhong Nanshan said on Friday that using a different type of vaccine for a booster dose is recommended in sequential immunization in China, as using a different shot can offer better protection.
 

Globally, many Western countries are adopting a strategy of living with the virus, but Zhong said that China will gradually reopen in the process of implementing the dynamic zero-COVID policy. A complete reopening would not be an option as the number of deaths would be increased significantly, he said.
 

Data shows that for people who received two inactivated Sinovac vaccine shots and one mRNA vaccine for a booster shot, the protection rate can reach as high as 92.7 percent 14 to 30 days after the booster shot and the effective rate for preventing severe cases was 97.3 percent, Zhong said.
 

Zhong said that after two doses of inactivated vaccine and one different type of shot, the activity level of antibodies was higher than from three doses of inactivated vaccine.
 

He said his booster shot was a protein subunit COVID-19 vaccine made by Anhui Zhifei Lingcom Biopharmaceuticals.
 

China is currently rolling out sequential immunization and mixing different types of vaccines to boost people's immune system. People can also have their booster shots using the same type of vaccine.
 

According to China's health commission, those who are fully vaccinated with inactivated vaccines can choose between a protein subunit COVID-19 vaccine made by Anhui Zhifei Lingcom Biopharmaceuticals and a viral vector vaccine developed by CanSino Biologics for a sequential COVID-19 booster shot.
 

Zhong said research into small-molecule drugs to protect against the Omicron variant is currently an important mission.
 

建议使用异种疫苗作为序贯接种

近日,钟南山院士团队通过实验室分析,新冠疫苗第三针接种异种疫苗可增强效果。钟南山院士认为,加强免疫势在必行,建议使用异种疫苗作为序贯接种。
 

钟南山院士近日表示,“最近刚刚在《nature medecine》上发表研究结果显示,巴西很多老百姓打中国的疫苗,打两针的(科兴灭活)疫苗,对新冠病毒的感染起到55%的预防(作用),对重症起到82%的预防(作用)。在180天后,第三针接种mrna疫苗,它的预防作用和对重症的预防作用,都有明显的增加。加强免疫势在必行。”
 

“根据在真实世界里观察的结果,三针灭活疫苗和三针mrna疫苗,对奥密克戎重症发生率的结果是相似的。”钟南山表示,“通过我们实验室对疫苗免疫原性的分析,观察其抗体的产生以及细胞免疫的能力,两针灭活疫苗接种以后,使用一针的异种疫苗,不管是mrna疫苗,或者是现在已经有的腺病毒疫苗,或者是国产已经有的亚单位蛋白疫苗,不管是哪一种,不要往同一种打,而是混打,其中中和抗体水平、特异性cd4水平的活性,都比三针的灭活疫苗高。”
 

钟南山院士表示,“根据这个情况,我自己第三针打的是智飞的疫苗。所以根据我国动态清零的战略,不单是要减少重症率和死亡率,同时要减少感染率,这样才能够达到动态清零的目标。所以从目前学术看法,异种疫苗作为序贯接种是比较可取的。当然,这需要更多的真实世界证实。”

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